British Pharmacopoeia Chemical reference substances (BPCRS)

These Primary standards are established using absolute methods and the declared content figures are determined without comparing to another substance. You should use BPCRS to perform the tests in the British Pharmacopoeia (BP) or BP (Veterinary). Do not eat BPCRS or feed them to animals – you should only use BPCRS for chemical analysis. They are not suitable for any other use.

30/06/2025

Dear valued customer,

We are writing to let you know that, due to an electrical fault, our freezers in which some BPCRS vial stock was stored switched off for a short period and the storage temperature may have been compromised over the weekend of 21st/22nd June. This was detected promptly and rectified, but as a precaution we have removed all affected items from sale and are conducting thorough testing to verify their stability and usability.

Consequently, you may notice in the short term that a higher number of products than usual are showing as “out of stock”. This process is necessary to ensure that only products that meet our quality standards are shipped to you.

We sincerely apologise for any inconvenience and appreciate your patience and understanding, and would like to reassure you that;

· None of the affected vials have been shipped to customers.

· All affected vials have been quarantined.

· We are urgently reviewing the material stability data and carrying out testing to determine if the material has been affected.

· We have additional bulk supplies of the materials which have not been affected and we can produce more vials from these bulks.

Products will be brought back into stock as soon as we can confirm they have not been affected. As we assess the products and gather more data we will be able to update with estimated timeframes in due course. As soon as we have further information we will update this page.

Update 18/07/25

We are pleased to update that over the last three weeks we have made the following products available for sale, following their temporary withdrawal resulting from an electrical fault affecting freezers.

This follows a detailed quality assessment of some of our vialled stock and re-vialing product from our reserved bulk supplies:

CAT 26 (azathioprine), CAT 108 (dexamethasone sodium phosphate), CAT 341 (3,5,6-trichloro-2-hydroxybenzoic acid), CAT 362 (naftidrofuryl oxalate), CAT 400 (rifampicin N-oxide), CAT 640 (N,N'-bis(2,4-xylyl)formamidine), CAT 641 (N-methyl-N'-(2,4-xylyl)formamidine), CAT 654 (famotidine impurity C), CAT 704 (salbutamol ketone impurity), CAT 781 (erythromycin), CAT 789 (demeclocycline hydrochloride), CAT 791 (delta-3-cefaclor), CAT 876 (tamsulosin hydrochloride), CAT 894 (budesonide impurity standard), CAT 1027 (piperacillin), CAT 1030 (pravastatin impurity A), CAT 1106 (nicorandil amide), CAT 1150 (colchicine), CAT 1165 (palmatine chloride), CAT 1167 (vecuronium bromide), CAT 1193 (quinapril hydrochloride).

We are continuing to review all remaining affected products, with further products expected to be made available next week, and most affected items expected to be made available by the end of July.

We would like to thank you again for your patience while we have worked to resolve this matter.

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  • Search result 1

    Category Number 764
    Pack size 25 mg
    Substance name oxibendazole
    Declared content Not applicable
    Current batch 2945
    QTY (Max 25)
  • Search result 2

    Category Number 700
    Pack size 100 mg
    Substance name oxybuprocaine hydrochloride
    Declared content
    99.8% of C17H28N2O3,HCl
    Current batch 3804
    QTY (Max 25)
  • Search result 3

    Category Number 701
    Pack size 100 mg
    Substance name oxybutynin hydrochloride
    Declared content
    97.6% of C22H31NO3,HCl
    Current batch 3921
    QTY (Max 25)
  • Search result 4

    Category Number 273
    Pack size 200 mg
    Substance name oxyclozanide
    Declared content Not applicable
    Current batch 4016
    QTY (Max 2)
  • Search result 5

    Category Number 1068
    Pack size 100 mg
    Substance name oxycodone hydrochloride
    Declared content
    93.8% of C18H21NO4, HCl
    Current batch 4211
    Out of Stock
  • Search result 6

    Category Number 1136
    Pack size 25 mg
    Substance name oxycodone impurity standard
    Declared content Not applicable
    Current batch 3649
    QTY (Max 25)
  • Search result 7

    Category Number 416
    Pack size 1
    Substance name oxyphenbutazone
    Declared content Not applicable
    Current batch
    Discontinued
  • Search result 8

    Category Number 782
    Pack size 100 mg
    Substance name oxytetracycline
    Declared content
    88.1% of C22H24N2O9
    Current batch 2830
    QTY (Max 25)
  • Search result 9

    Category Number 275
    Pack size 20 mg
    Substance name oxytetracycline hydrochloride
    Declared content Not applicable
    Current batch 4082
    Out of Stock
  • Search result 10

    Category Number 769
    Pack size 20 mg
    Substance name paeoniflorin
    Declared content
    88.6% of C23H28O11
    Current batch 3571
    E-mail to order:  bpcrs@mhra.gov.uk
  • Search result 11

    Category Number 1165
    Pack size 100 mg
    Substance name palmatine chloride
    Declared content
    79.1% of C21H22CINO4
    Current batch 4200
    QTY (Max 25)
  • Search result 12

    Category Number 276
    Pack size 25 mg
    Substance name pancuronium bromide
    Declared content
    92.2% of C35H60Br2N2O4
    Current batch 3863
    Out of Stock
  • Search result 13

    Category Number 1198
    Pack size 25 mg
    Substance name pantoprazole impurity A
    Declared content Not applicable
    Current batch 3903
    QTY (Max 25)
  • Search result 14

    Category Number 1197
    Pack size 100 mg
    Substance name pantoprazole sodium
    Declared content
    88.4% of C16H14F2N3O4S
    Current batch 3902
    QTY (Max 25)
  • Search result 15

    Category Number 277
    Pack size 100 mg
    Substance name papaverine hydrochloride
    Declared content
    90.0% of C20H21NO4
    99.7% of C20H21NO4,HCl
    Current batch 2715
    QTY (Max 25)
  • Search result 16

    Category Number 371
    Pack size 100 mg
    Substance name paracetamol
    Declared content
    99.8% of C8H9NO2
    Current batch 4436
    Out of Stock
  • Search result 17

    Category Number 1024
    Pack size 200 mg
    Substance name paroxetine hydrochloride hemihydrate
    Declared content
    97.4% of C19H20FNO3,HCl
    Current batch 3241
    QTY (Max 25)
  • Search result 18

    Category Number 746
    Pack size 25 mg
    Substance name paroxetine impurity standard
    Declared content Not applicable
    Current batch 4468
    QTY (Max 25)
  • Search result 19

    Category Number 278
    Pack size 5 mg
    Substance name pentagastrin
    Declared content Not applicable
    Current batch 3204
    Out of Stock
  • Search result 20

    Category Number 1073
    Pack size 100 mg
    Substance name perindopril erbumine
    Declared content
    99.7% of C23H43N3O5
    Current batch 4167
    QTY (Max 25)