British Pharmacopoeia Chemical reference substances (BPCRS)

These Primary standards are established using absolute methods and the declared content figures are determined without comparing to another substance. You should use BPCRS to perform the tests in the British Pharmacopoeia (BP) or BP (Veterinary). Do not eat BPCRS or feed them to animals – you should only use BPCRS for chemical analysis. They are not suitable for any other use.

30/06/2025

Dear valued customer,

We are writing to let you know that, due to an electrical fault, our freezers in which some BPCRS vial stock was stored switched off for a short period and the storage temperature may have been compromised over the weekend of 21st/22nd June. This was detected promptly and rectified, but as a precaution we have removed all affected items from sale and are conducting thorough testing to verify their stability and usability.

Consequently, you may notice in the short term that a higher number of products than usual are showing as “out of stock”. This process is necessary to ensure that only products that meet our quality standards are shipped to you.

We sincerely apologise for any inconvenience and appreciate your patience and understanding, and would like to reassure you that;

· None of the affected vials have been shipped to customers.

· All affected vials have been quarantined.

· We are urgently reviewing the material stability data and carrying out testing to determine if the material has been affected.

· We have additional bulk supplies of the materials which have not been affected and we can produce more vials from these bulks.

Products will be brought back into stock as soon as we can confirm they have not been affected. As we assess the products and gather more data we will be able to update with estimated timeframes in due course. As soon as we have further information we will update this page.

Update 18/07/25

We are pleased to update that over the last three weeks we have made the following products available for sale, following their temporary withdrawal resulting from an electrical fault affecting freezers.

This follows a detailed quality assessment of some of our vialled stock and re-vialing product from our reserved bulk supplies:

CAT 26 (azathioprine), CAT 108 (dexamethasone sodium phosphate), CAT 341 (3,5,6-trichloro-2-hydroxybenzoic acid), CAT 362 (naftidrofuryl oxalate), CAT 400 (rifampicin N-oxide), CAT 640 (N,N'-bis(2,4-xylyl)formamidine), CAT 641 (N-methyl-N'-(2,4-xylyl)formamidine), CAT 654 (famotidine impurity C), CAT 704 (salbutamol ketone impurity), CAT 781 (erythromycin), CAT 789 (demeclocycline hydrochloride), CAT 791 (delta-3-cefaclor), CAT 876 (tamsulosin hydrochloride), CAT 894 (budesonide impurity standard), CAT 1027 (piperacillin), CAT 1030 (pravastatin impurity A), CAT 1106 (nicorandil amide), CAT 1150 (colchicine), CAT 1165 (palmatine chloride), CAT 1167 (vecuronium bromide), CAT 1193 (quinapril hydrochloride).

We are continuing to review all remaining affected products, with further products expected to be made available next week, and most affected items expected to be made available by the end of July.

We would like to thank you again for your patience while we have worked to resolve this matter.

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  • Search result 1

    Category Number 1141
    Pack size 25 mg
    Substance name glimepiride for system suitability
    Declared content Not applicable
    Current batch 4864
    QTY (Max 25)
  • Search result 2

    Category Number 580
    Pack size 150 mg
    Substance name gliquidone
    Declared content
    99.7 % of C27H33N3O6S
    Current batch 3880
    Discontinued
  • Search result 3

    Category Number 581
    Pack size 25 mg
    Substance name gliquidone sulfonamide
    Declared content Not applicable
    Current batch 2006
    QTY (Max 25)
  • Search result 4

    Category Number 652
    Pack size 5 ml
    Substance name glyceryl trinitrate solution
    Declared content
    0.9939% w/w of C3H5N3O9 solution or 1.0337% w/v of C3H5N3O9 solution
    Current batch 4772
    E-mail to order:  bpcrs@mhra.gov.uk
  • Search result 5

    Category Number 1110
    Pack size 100 mg
    Substance name glycopyrronium bromide
    Declared content
    99.9% of C19H28BrNO3
    Current batch 4718
    QTY (Max 25)
  • Search result 6

    Category Number 814
    Pack size 10 mg
    Substance name goserelin hexapeptide
    Declared content Not applicable
    Current batch 2893
    QTY (Max 25)
  • Search result 7

    Category Number 180
    Pack size 1
    Substance name griseofulvin
    Declared content
    98.3 % of C17H17ClO6 for GC
    99.8% of C17H17ClO6 for UV
    Current batch 4023
    Discontinued
  • Search result 8

    Category Number 181
    Pack size 100 mg
    Substance name guanethidine monosulfate
    Declared content
    99.5% of C10H22N4,H2SO4
    Current batch 2430
    QTY (Max 25)
  • Search result 9

    Category Number 879
    Pack size 25 mg
    Substance name guanine
    Declared content Not applicable
    Current batch 3128
    QTY (Max 25)
  • Search result 10

    Category Number 407
    Pack size 150 mg
    Substance name haloperidol
    Declared content
    99.8 % of C21H23ClFNO2
    Current batch 4358
    QTY (Max 25)
  • Search result 11

    Category Number 182
    Pack size 1
    Substance name haloxon
    Declared content Not applicable
    Current batch
    Discontinued
  • Search result 12

    Category Number 185
    Pack size 100 mg
    Substance name homatropine hydrobromide
    Declared content
    99.7% of C16H21NO3.HBr
    Current batch 4371
    QTY (Max 25)
  • Search result 13

    Category Number 186
    Pack size 200 mg
    Substance name hydrochlorothiazide
    Declared content
    99.3% of C7H8ClN3O4S2
    Current batch 3093
    QTY (Max 25)
  • Search result 14

    Category Number 576
    Pack size 100 mg
    Substance name hydrocortisone
    Declared content
    99.5% of C21H30O5
    Current batch 4355
    Out of Stock
  • Search result 15

    Category Number 584
    Pack size 100 mg
    Substance name hydrocortisone acetate
    Declared content
    98.8% of C23H32O6
    Current batch 3338
    QTY (Max 25)
  • Search result 16

    Category Number 187
    Pack size 100 mg
    Substance name hydrocortisone hydrogen succinate
    Declared content Not applicable
    Current batch 4386
    Out of Stock
  • Search result 17

    Category Number 188
    Pack size 100 mg
    Substance name hydrocortisone sodium phosphate
    Declared content Not applicable
    Current batch 3325
    QTY (Max 25)
  • Search result 18

    Category Number 190
    Pack size 100 mg
    Substance name hydroflumethiazide
    Declared content Not applicable
    Current batch 1931
    QTY (Max 25)
  • Search result 19

    Category Number 1206
    Pack size 100 mg
    Substance name hydroquinone
    Declared content
    99.7% of C6H6O2
    Current batch 3950
    QTY (Max 25)
  • Search result 20

    Category Number 197
    Pack size 200 mg
    Substance name hydroxycarbamide
    Declared content
    99.6% of CH4N2O2
    Current batch 3545
    QTY (Max 25)